Modulación de la respuesta a insulina en el ovario bovino y su relación con la enfermedad quística ovárica
Resumen
La enfermedad quística ovárica bovina es una importante enfermedad que afecta la fertilidad del ganado bovino lechero. Diversos procesos ováricos tales como la proliferación celular y la esteroidogénesis se encuentran regulados por numerosas hormonas entre las que se encuentra la insulina. La respuesta a esta hormona se desencadena luego de la unión a su receptor específico. El objetivo de la presente revisión es analizar la función de intermediarios claves en la vía de señalización intracelular, que actúan en los primeros estadios involucrados en la respuesta a insulina. Se analizan el receptor de insulina (IR), el sustrato -1 del IR (IRS1) y la enzima fosfatidilinositol 3-quinasa (PI3K) denotando modificaciones ocurridas en folículos quísticos que podrían influenciar negativamente en la funcionalidad de ovarios y contribuir a la persistencia folicular.
Palabras clave: insulina, ovario, bovinos, enfermedad quística ovárica.
Descargas
Los datos de descargas todavía no están disponibles.
Citas
Alam H, Maizels ET, Park Y, Ghaey S, Feiger ZJ, Chandel NS, Hunzicker-Dunn M (2004) Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follic. J Biol Chem 279: 19431–19440.
Amweg AN, Salvetti NR, Stangaferro ML, Paredes AH, Lara HH, Rodríguez FM, Ortega HH (2013) Ovarian localization of 11β- hydroxysteroid dehydrogenase (11βHSD): effects of ACTH stimulation and its relationship with bovine cystic ovarian disease. Domest Anim Endocrinol 45: 126–140.
Baba T, Endo T, Sata F, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Yamada H, Minakami H, Kishi R, Saito T (2007) Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population. Life Sci 81: 850–854.
Bauman DE, Currie WB (1980) Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. J Dairy Sci 63: 1514–1529.
Bossaert P, Leroy JLMR, De Vliegher S, Opsomer G (2008) Interrelations between glucose-induced insulin response, metabolic indicators, and time of first ovulation in high-yielding dairy cows. J Dairy Sci 91: 3363–3371.
Bossaert P, De Cock H, Leroy JLMR, De Campeneere S, Bols PEJ, Filliers M, Opsomer G (2010) Immunohistochemical visualization of insulin receptors in formalin-fixed bovine ovaries post mortem and in granulosa cells collected in vivo. Theriogenology 73: 1210–1219.
Burks DJ, Font de Mora J, Schubert M, Withers DJ, Myers MG, Towery HH, Altamuro SL, Flint CL, White MF (2000) IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407: 377–382.
Butler ST, Pelton SH, Butler WR (2004) Insulin increases 17 beta-estradiol production by the dominant follicle of the first postpartum follicle wave in dairy cows. Reproduction 127: 537–545.
Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296: 1655–1657.
Cattaneo L, Signorini ML, Bertoli J, Bartolomé JA, Gareis NC, Díaz PU, Bó GA, Ortega HH (2014) Epidemiological description of cystic ovarian disease in argentine dairy herds: risk factors and effects on the reproductive performance of lactating cows. Reprod Domest Anim 49: 1028–1033.
Davoren JB, Kasson BG, Li CH, Hsueh AJ (1986) Specific insulin-like growth factor (IGF) I- and II-binding sites on rat granulosa cells: relation to IGF action. Endocrinology 119: 2155–2162.
Devoto L, Christenson LK, McAllister JM, Makrigiannakis A, Strauss JF (1999) Insulin and insulin-like growth factor-I and -II modulate human granulosa-lutein cell steroidogenesis: enhancement of steroidogenic acute regulatory protein (StAR) expression. Mol Hum Reprod 5: 1003–1010.
Dobson H, Smith RF (2000) What is stress, and how does it affect reproduction? Anim Reprod Sci 60-61: 743–752.
Diskin MG, Mackey DR, Roche JF, Sreenan JM (2003) Effects of nutrition and metabolic status on circulating hormones and ovarian follicle development in cattle. Anim Reprod Sci 78: 345–370.
Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Ou JH, Masiarz F, Kan YW, Goldfine ID (1985) The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell 40: 747–758.
Garverick HA (1997) Ovarian follicular cysts in dairy cows. J Dairy Sci 80: 995–1004.
Gonzalez-Robayna IJ, Falender AE, Ochsner S, Firestone GL, Richards JS (2000) Follicle-Stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinaseindependent signaling by FSH in granulosa cells. Mol Endocrinol 14: 1283–1300.
Gutiérrez CG, Campbell BK, Armstrong DG, Webb R (1997) Insulin-like growth factor-I (IGF-I) production by bovine granulosa cells in vitro and peripheral IGF-I measurement in cattle serum: an evaluation of IGF-binding protein extraction protocols. J Endocrinol 153: 231–240.
Hein GJ, Chicco A, Lombardo YB (2012) Fish oil normalizes plasma glucose levels and improves liver carbohydrate metabolism in rats fed a sucrose-rich diet. Lipids 47: 141–150.
Hein GJ, Panzani CG, Rodríguez FM, Salvetti NR, Díaz PU, Gareis NC, Benítez GA, Ortega HH, Rey F (2015) Impaired insulin signaling pathway in ovarian follicles of cows with cystic ovarian disease. Anim Reprod Sci 156: 64–74.
Isobe N, Yoshimura Y (2007) Deficient proliferation and apoptosis in the granulosa and theca interna cells of the bovine cystic follicle. J Reprod Dev 53: 1119–1124.
Kawashima C, Fukihara S, Maeda M, Kaneko E, Montoya CA, Matsui M, Shimizu T, Matsunaga N, Kida K, Miyake YI, Schams D, Miyamoto A (2007) Relationship between metabolic hormones and ovulation of dominant follicle during the first follicular wave post-partum in highproducing dairy cows. Reproduction 133: 155–163.
Kawashima C, Matsui M, Shimizu T, Kida K, Miyamoto A (2012) Nutritional factors that regulate ovulation of the dominant follicle during the first follicular wave postpartum in high-producing dairy cows. J Reprod Dev 58: 10–16.
Landau S, Braw-Tal R, Kaim M, Bor A, Bruckental I (2000) Preovulatory follicular status and diet affect the insulin and glucose content of follicles in high-yielding dairy cows. Anim Reprod Sci 64: 181–197.
Ledoux S, Campos DB, Lopes FL, Dobias-Goff M, Palin MF, Murphy BD (2006) Adiponectin induces periovulatory changes in ovarian follicular cells. Endocrinology 147: 5178–5186.
Leroy JLMR, Vanholder T, Van Knegsel ATM, Garcia-Ispierto I, Bols PEJ (2008) Nutrient prioritization in dairy cows early postpartum: mismatch between metabolism and fertility? Reprod Domest Anim 43 Suppl 2: 96–103.
Lima MHM, Souza LC, Caperuto LC, Bevilacqua E, Gasparetti AL, Zanuto R, Saad MJA, Carvalho CRO (2006) Up-regulation of the phosphatidylinositol 3-kinase/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin. J Endocrinol 190: 451–459.
Llewellyn S, Fitzpatrick R, Kenny DA, Murphy JJ, Scaramuzzi RJ, Wathes DC (2007) Effect of negative energy balance on the insulin-like growth factor system in pre-recruitment ovarian follicles of post partum dairy cows. Reproduction 133: 627–639.
Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL (2012) Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem 287: 4518–4530.
Mani AM, Fenwick MA, Cheng Z, Sharma MK, Singh D, Wathes DC (2010) IGF1 induces up-regulation of steroidogenic and apoptotic regulatory genes via activation of phosphatidylinositol-dependent kinase/AKT in bovine granulosa cells. Reproduction 139: 139–151.
Miyoshi S, Pate JL, Palmquist DL (2001) Effects of propylene glycol drenching on energy balance, plasma glucose, plasma insulin, ovarian function and conception in dairy cows. Anim Reprod Sci 68: 29–43.
Opsomer G, Wensing T, Laevens H, Coryn M, de Kruif A (1999) Insulin resistance: the link between metabolic disorders and cystic ovarian disease in high yielding dairy cows? Anim Reprod Sci 56: 211–222.
Ortega HH, Palomar MM, Acosta JC, Salvetti NR, Dallard BE, Lorente JA, Barbeito CG, Gimeno EJ (2008) Insulin-like growth factor I in sera, ovarian follicles and follicular fluid of cows with spontaneous or induced cystic ovarian disease. Res Vet Sci 84: 419–427.
Ortega HH, Rey F, Velazquez MML, Padmanabhan V (2010) Developmental programming: effect of prenatal steroid excess on intraovarian components of insulin signaling pathway and related proteins in sheep. Biol Reprod 82: 1065–1075.
Pagliassotti MJ, Kang J, Thresher JS, Sung CK, Bizeau ME (2002) Elevated basal PI 3-kinase activity and reduced insulin signaling in sucroseinduced hepatic insulin resistance. Am J Physiol Endocrinol Metab 282: E170–176.
Palaniappan M, Menon B, Menon KMJ (2013) Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway. Mol Cell Endocrinol 366: 81–89.
Perry RC, Corah LR, Kiracofe GH, Stevenson JS, Beal WE (1991) Endocrine changes and ultrasonography of ovaries in suckled beef cows during resumption of postpartum estrous cycles. J Anim Sci 69: 2548–2555.
Peter AT (2004) An Update on Cystic Ovarian Degeneration in Cattle. Reprod Domest Anim 39: 1–7.
Phy JL, Conover CA, Abbott DH, Zschunke MA, Walker DL, Session DR, Tummon IS, Thornhill AR, Lesnick TG, Dumesic DA (2004) Insulin and messenger ribonucleic acid expression of insulin receptor isoforms in ovarian follicles from nonhirsute ovulatory women and polycystic ovary syndrome patients. J Clin Endocrinol Metab 89: 3561–3566.
Pirola L, Bonnafous S, Johnston AM, Chaussade C, Portis F, Van Obberghen E (2003) Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells. J Biol Chem 278: 15641–15651.
Rey F, Rodríguez FM, Salvetti NR, Palomar MM, Barbeito CG, Alfaro NS, Ortega HH (2010) Insulin-like growth factor-II and insulin-like growth factor-binding proteins in bovine cystic ovarian disease. J Comp Pathol 142: 193–204.
Rodríguez FM, Salvetti NR, Colombero M, Stangaferro ML, Barbeito CG, Ortega HH, Rey F (2013) Interaction between IGF1 and IGFBPs in bovine cystic ovarian disease. Anim Reprod Sci 140: 14–25.
Royal M, Darwash A, Flint A, Webb R, Woolliams J, Lamming G (2000) Declining fertility in dairy cattle: changes in traditional and endocrine parameters of fertility. Anim Sci 70: 487–501.
Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799–806.
Salvetti NR, Stangaferro ML, Palomar MM, Alfaro NS, Rey F, Gimeno EJ, Ortega HH (2010) Cell proliferation and survival mechanisms underlying the abnormal persistence of follicular cysts in bovines with cystic ovarian disease induced by ACTH. Anim Reprod Sci 122: 98–110.
Samoto T, Maruo T, Ladines-Llave CA, Matsuo H, Deguchi J, Barnea ER, Mochizuki M (1993) Insulin receptor expression in follicular and stromal compartments of the human ovary over the course of follicular growth, regression and atresia. Endocr J 40: 715–726.
Seto-Young D, Avtanski D, Strizhevsky M, Parikh G, Patel P, Kaplun J, Holcomb K, Rosenwaks Z, Poretsky L (2007) Interactions among peroxisome proliferator activated receptor-gamma, insulin signaling pathways, and steroidogenic acute regulatory protein in human ovarian cells. J Clin Endocrinol Metab 92: 2232–2239.
Silva JM, Hamel M, Sahmi M, Price CA (2006) Control of oestradiol secretion and of cytochrome P450 aromatase messenger ribonucleic acid accumulation by FSH involves different intracellular pathways in oestrogenic bovine granulosa cells in vitro. Reproduction 132: 909–917.
Silvia WJ, Hatler TB, Nugent AM, Laranja Da Fonseca LF (2002) Ovarian follicular cysts in dairy cows: An abnormality in folliculogenesis. Domest. Anim. Endocrinol. pp 167–177.
Simpson RB, Chase CC, Spicer LJ, Vernon RK, Hammond AC, Rae DO (1994) Effect of exogenous insulin on plasma and follicular insulinlike growth factor I, insulin-like growth factor binding protein activity, follicular oestradiol and progesterone, and follicular growth in superovulated Angus and Brahman cows. J Reprod Fertil 102: 483–492.
Shimizu T, Murayama C, Sudo N, Kawashima C, Tetsuka M, Miyamoto A (2008) Involvement of insulin and growth hormone (GH) during follicular development in the bovine ovary. Anim Reprod Sci 106: 143–152.
Spicer LJ, Chamberlain CS, Maciel SM (2002) Influence of gonadotropins on insulin- and insulin-like growth factor-I (IGF-I)-induced steroid production by bovine granulosa cells. Domest Anim Endocrinol 22: 237–254.
Stewart RE, Spicer LJ, Hamilton TD, Keefer BE (1995) Effects of insulin-like growth factor I and insulin on proliferation and on basal and luteinizing hormone-induced steroidogenesis of bovine thecal cells: involvement of glucose and receptors for insulin-like growth factor I and luteinizing hormone. J Anim Sci 73: 3719–3731.
Taniguchi CM, Emanuelli B, Kahn CR (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7: 85–96.
Vanholder T, Opsomer G, de Kruif A (2006) Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review. Reprod Nutr Dev 46: 105–119.
Vanholder T, Leroy JLMR, Dewulf J, Duchateau L, Coryn M, de Kruif A, Opsomer G (2005) Hormonal and metabolic profiles of highyielding dairy cows prior to ovarian cyst formation or first ovulation post partum. Reprod Domest Anim 40: 460–467.
Walsh SW, Mehta JP, McGettigan PA, Browne JA, Forde N, Alibrahim RM, Mulligan FJ, Loftus B, Crowe MA, Matthews D, Diskin M, Mihm M, Evans ACO (2012) Effect of the metabolic environment at key stages of follicle development in cattle: focus on steroid biosynthesis. Physiol Genomics 44: 504–517.
White MF (1998) The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol Cell Biochem 182: 3–11.
Yen H, Jakimiuk AJ, Munir I, Magoffin DA (2004) Selective alterations in insulin receptor substrates-1 , -2 and -4 in theca but not granulosa cells from polycystic ovaries. 10: 473–479.
Amweg AN, Salvetti NR, Stangaferro ML, Paredes AH, Lara HH, Rodríguez FM, Ortega HH (2013) Ovarian localization of 11β- hydroxysteroid dehydrogenase (11βHSD): effects of ACTH stimulation and its relationship with bovine cystic ovarian disease. Domest Anim Endocrinol 45: 126–140.
Baba T, Endo T, Sata F, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Yamada H, Minakami H, Kishi R, Saito T (2007) Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population. Life Sci 81: 850–854.
Bauman DE, Currie WB (1980) Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. J Dairy Sci 63: 1514–1529.
Bossaert P, Leroy JLMR, De Vliegher S, Opsomer G (2008) Interrelations between glucose-induced insulin response, metabolic indicators, and time of first ovulation in high-yielding dairy cows. J Dairy Sci 91: 3363–3371.
Bossaert P, De Cock H, Leroy JLMR, De Campeneere S, Bols PEJ, Filliers M, Opsomer G (2010) Immunohistochemical visualization of insulin receptors in formalin-fixed bovine ovaries post mortem and in granulosa cells collected in vivo. Theriogenology 73: 1210–1219.
Burks DJ, Font de Mora J, Schubert M, Withers DJ, Myers MG, Towery HH, Altamuro SL, Flint CL, White MF (2000) IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407: 377–382.
Butler ST, Pelton SH, Butler WR (2004) Insulin increases 17 beta-estradiol production by the dominant follicle of the first postpartum follicle wave in dairy cows. Reproduction 127: 537–545.
Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296: 1655–1657.
Cattaneo L, Signorini ML, Bertoli J, Bartolomé JA, Gareis NC, Díaz PU, Bó GA, Ortega HH (2014) Epidemiological description of cystic ovarian disease in argentine dairy herds: risk factors and effects on the reproductive performance of lactating cows. Reprod Domest Anim 49: 1028–1033.
Davoren JB, Kasson BG, Li CH, Hsueh AJ (1986) Specific insulin-like growth factor (IGF) I- and II-binding sites on rat granulosa cells: relation to IGF action. Endocrinology 119: 2155–2162.
Devoto L, Christenson LK, McAllister JM, Makrigiannakis A, Strauss JF (1999) Insulin and insulin-like growth factor-I and -II modulate human granulosa-lutein cell steroidogenesis: enhancement of steroidogenic acute regulatory protein (StAR) expression. Mol Hum Reprod 5: 1003–1010.
Dobson H, Smith RF (2000) What is stress, and how does it affect reproduction? Anim Reprod Sci 60-61: 743–752.
Diskin MG, Mackey DR, Roche JF, Sreenan JM (2003) Effects of nutrition and metabolic status on circulating hormones and ovarian follicle development in cattle. Anim Reprod Sci 78: 345–370.
Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Ou JH, Masiarz F, Kan YW, Goldfine ID (1985) The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell 40: 747–758.
Garverick HA (1997) Ovarian follicular cysts in dairy cows. J Dairy Sci 80: 995–1004.
Gonzalez-Robayna IJ, Falender AE, Ochsner S, Firestone GL, Richards JS (2000) Follicle-Stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinaseindependent signaling by FSH in granulosa cells. Mol Endocrinol 14: 1283–1300.
Gutiérrez CG, Campbell BK, Armstrong DG, Webb R (1997) Insulin-like growth factor-I (IGF-I) production by bovine granulosa cells in vitro and peripheral IGF-I measurement in cattle serum: an evaluation of IGF-binding protein extraction protocols. J Endocrinol 153: 231–240.
Hein GJ, Chicco A, Lombardo YB (2012) Fish oil normalizes plasma glucose levels and improves liver carbohydrate metabolism in rats fed a sucrose-rich diet. Lipids 47: 141–150.
Hein GJ, Panzani CG, Rodríguez FM, Salvetti NR, Díaz PU, Gareis NC, Benítez GA, Ortega HH, Rey F (2015) Impaired insulin signaling pathway in ovarian follicles of cows with cystic ovarian disease. Anim Reprod Sci 156: 64–74.
Isobe N, Yoshimura Y (2007) Deficient proliferation and apoptosis in the granulosa and theca interna cells of the bovine cystic follicle. J Reprod Dev 53: 1119–1124.
Kawashima C, Fukihara S, Maeda M, Kaneko E, Montoya CA, Matsui M, Shimizu T, Matsunaga N, Kida K, Miyake YI, Schams D, Miyamoto A (2007) Relationship between metabolic hormones and ovulation of dominant follicle during the first follicular wave post-partum in highproducing dairy cows. Reproduction 133: 155–163.
Kawashima C, Matsui M, Shimizu T, Kida K, Miyamoto A (2012) Nutritional factors that regulate ovulation of the dominant follicle during the first follicular wave postpartum in high-producing dairy cows. J Reprod Dev 58: 10–16.
Landau S, Braw-Tal R, Kaim M, Bor A, Bruckental I (2000) Preovulatory follicular status and diet affect the insulin and glucose content of follicles in high-yielding dairy cows. Anim Reprod Sci 64: 181–197.
Ledoux S, Campos DB, Lopes FL, Dobias-Goff M, Palin MF, Murphy BD (2006) Adiponectin induces periovulatory changes in ovarian follicular cells. Endocrinology 147: 5178–5186.
Leroy JLMR, Vanholder T, Van Knegsel ATM, Garcia-Ispierto I, Bols PEJ (2008) Nutrient prioritization in dairy cows early postpartum: mismatch between metabolism and fertility? Reprod Domest Anim 43 Suppl 2: 96–103.
Lima MHM, Souza LC, Caperuto LC, Bevilacqua E, Gasparetti AL, Zanuto R, Saad MJA, Carvalho CRO (2006) Up-regulation of the phosphatidylinositol 3-kinase/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin. J Endocrinol 190: 451–459.
Llewellyn S, Fitzpatrick R, Kenny DA, Murphy JJ, Scaramuzzi RJ, Wathes DC (2007) Effect of negative energy balance on the insulin-like growth factor system in pre-recruitment ovarian follicles of post partum dairy cows. Reproduction 133: 627–639.
Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL (2012) Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem 287: 4518–4530.
Mani AM, Fenwick MA, Cheng Z, Sharma MK, Singh D, Wathes DC (2010) IGF1 induces up-regulation of steroidogenic and apoptotic regulatory genes via activation of phosphatidylinositol-dependent kinase/AKT in bovine granulosa cells. Reproduction 139: 139–151.
Miyoshi S, Pate JL, Palmquist DL (2001) Effects of propylene glycol drenching on energy balance, plasma glucose, plasma insulin, ovarian function and conception in dairy cows. Anim Reprod Sci 68: 29–43.
Opsomer G, Wensing T, Laevens H, Coryn M, de Kruif A (1999) Insulin resistance: the link between metabolic disorders and cystic ovarian disease in high yielding dairy cows? Anim Reprod Sci 56: 211–222.
Ortega HH, Palomar MM, Acosta JC, Salvetti NR, Dallard BE, Lorente JA, Barbeito CG, Gimeno EJ (2008) Insulin-like growth factor I in sera, ovarian follicles and follicular fluid of cows with spontaneous or induced cystic ovarian disease. Res Vet Sci 84: 419–427.
Ortega HH, Rey F, Velazquez MML, Padmanabhan V (2010) Developmental programming: effect of prenatal steroid excess on intraovarian components of insulin signaling pathway and related proteins in sheep. Biol Reprod 82: 1065–1075.
Pagliassotti MJ, Kang J, Thresher JS, Sung CK, Bizeau ME (2002) Elevated basal PI 3-kinase activity and reduced insulin signaling in sucroseinduced hepatic insulin resistance. Am J Physiol Endocrinol Metab 282: E170–176.
Palaniappan M, Menon B, Menon KMJ (2013) Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway. Mol Cell Endocrinol 366: 81–89.
Perry RC, Corah LR, Kiracofe GH, Stevenson JS, Beal WE (1991) Endocrine changes and ultrasonography of ovaries in suckled beef cows during resumption of postpartum estrous cycles. J Anim Sci 69: 2548–2555.
Peter AT (2004) An Update on Cystic Ovarian Degeneration in Cattle. Reprod Domest Anim 39: 1–7.
Phy JL, Conover CA, Abbott DH, Zschunke MA, Walker DL, Session DR, Tummon IS, Thornhill AR, Lesnick TG, Dumesic DA (2004) Insulin and messenger ribonucleic acid expression of insulin receptor isoforms in ovarian follicles from nonhirsute ovulatory women and polycystic ovary syndrome patients. J Clin Endocrinol Metab 89: 3561–3566.
Pirola L, Bonnafous S, Johnston AM, Chaussade C, Portis F, Van Obberghen E (2003) Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells. J Biol Chem 278: 15641–15651.
Rey F, Rodríguez FM, Salvetti NR, Palomar MM, Barbeito CG, Alfaro NS, Ortega HH (2010) Insulin-like growth factor-II and insulin-like growth factor-binding proteins in bovine cystic ovarian disease. J Comp Pathol 142: 193–204.
Rodríguez FM, Salvetti NR, Colombero M, Stangaferro ML, Barbeito CG, Ortega HH, Rey F (2013) Interaction between IGF1 and IGFBPs in bovine cystic ovarian disease. Anim Reprod Sci 140: 14–25.
Royal M, Darwash A, Flint A, Webb R, Woolliams J, Lamming G (2000) Declining fertility in dairy cattle: changes in traditional and endocrine parameters of fertility. Anim Sci 70: 487–501.
Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799–806.
Salvetti NR, Stangaferro ML, Palomar MM, Alfaro NS, Rey F, Gimeno EJ, Ortega HH (2010) Cell proliferation and survival mechanisms underlying the abnormal persistence of follicular cysts in bovines with cystic ovarian disease induced by ACTH. Anim Reprod Sci 122: 98–110.
Samoto T, Maruo T, Ladines-Llave CA, Matsuo H, Deguchi J, Barnea ER, Mochizuki M (1993) Insulin receptor expression in follicular and stromal compartments of the human ovary over the course of follicular growth, regression and atresia. Endocr J 40: 715–726.
Seto-Young D, Avtanski D, Strizhevsky M, Parikh G, Patel P, Kaplun J, Holcomb K, Rosenwaks Z, Poretsky L (2007) Interactions among peroxisome proliferator activated receptor-gamma, insulin signaling pathways, and steroidogenic acute regulatory protein in human ovarian cells. J Clin Endocrinol Metab 92: 2232–2239.
Silva JM, Hamel M, Sahmi M, Price CA (2006) Control of oestradiol secretion and of cytochrome P450 aromatase messenger ribonucleic acid accumulation by FSH involves different intracellular pathways in oestrogenic bovine granulosa cells in vitro. Reproduction 132: 909–917.
Silvia WJ, Hatler TB, Nugent AM, Laranja Da Fonseca LF (2002) Ovarian follicular cysts in dairy cows: An abnormality in folliculogenesis. Domest. Anim. Endocrinol. pp 167–177.
Simpson RB, Chase CC, Spicer LJ, Vernon RK, Hammond AC, Rae DO (1994) Effect of exogenous insulin on plasma and follicular insulinlike growth factor I, insulin-like growth factor binding protein activity, follicular oestradiol and progesterone, and follicular growth in superovulated Angus and Brahman cows. J Reprod Fertil 102: 483–492.
Shimizu T, Murayama C, Sudo N, Kawashima C, Tetsuka M, Miyamoto A (2008) Involvement of insulin and growth hormone (GH) during follicular development in the bovine ovary. Anim Reprod Sci 106: 143–152.
Spicer LJ, Chamberlain CS, Maciel SM (2002) Influence of gonadotropins on insulin- and insulin-like growth factor-I (IGF-I)-induced steroid production by bovine granulosa cells. Domest Anim Endocrinol 22: 237–254.
Stewart RE, Spicer LJ, Hamilton TD, Keefer BE (1995) Effects of insulin-like growth factor I and insulin on proliferation and on basal and luteinizing hormone-induced steroidogenesis of bovine thecal cells: involvement of glucose and receptors for insulin-like growth factor I and luteinizing hormone. J Anim Sci 73: 3719–3731.
Taniguchi CM, Emanuelli B, Kahn CR (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7: 85–96.
Vanholder T, Opsomer G, de Kruif A (2006) Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review. Reprod Nutr Dev 46: 105–119.
Vanholder T, Leroy JLMR, Dewulf J, Duchateau L, Coryn M, de Kruif A, Opsomer G (2005) Hormonal and metabolic profiles of highyielding dairy cows prior to ovarian cyst formation or first ovulation post partum. Reprod Domest Anim 40: 460–467.
Walsh SW, Mehta JP, McGettigan PA, Browne JA, Forde N, Alibrahim RM, Mulligan FJ, Loftus B, Crowe MA, Matthews D, Diskin M, Mihm M, Evans ACO (2012) Effect of the metabolic environment at key stages of follicle development in cattle: focus on steroid biosynthesis. Physiol Genomics 44: 504–517.
White MF (1998) The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol Cell Biochem 182: 3–11.
Yen H, Jakimiuk AJ, Munir I, Magoffin DA (2004) Selective alterations in insulin receptor substrates-1 , -2 and -4 in theca but not granulosa cells from polycystic ovaries. 10: 473–479.
Descargas
Publicado
2015-12-22
Cómo citar
PANZANI, C. G., HEIN, G. J., SALVETTI, N. R., ORTEGA, H. H., & REY, F. (2015). Modulación de la respuesta a insulina en el ovario bovino y su relación con la enfermedad quística ovárica. Revista Ciencias Morfológicas, 17(2). Recuperado a partir de https://revistas.unlp.edu.ar/Morfol/article/view/2451
Número
Sección
Trabajos Originales
Licencia
1. Política propuesta para revistas de acceso abierto
Los autores/as que publiquen en esta revista aceptan las siguientes condiciones:
- Los autores/as conservan los derechos de autor y ceden a la revista el derecho de la primera publicación, con el trabajo registrado con la licencia de atribución de Creative Commons, que permite a terceros utilizar lo publicado siempre que mencionen la autoría del trabajo y a la primera publicación en esta revista.
- Los autores/as pueden realizar otros acuerdos contractuales independientes y adicionales para la distribución no exclusiva de la versión del artículo publicado en esta revista (p. ej., incluirlo en un repositorio institucional o publicarlo en un libro) siempre que indiquen claramente que el trabajo se publicó por primera vez en esta revista.
- Se permite y recomienda a los autores/as a publicar su trabajo en Internet (por ejemplo en páginas institucionales o personales) despues del proceso de revisión y publicación, ya que puede conducir a intercambios productivos y a una mayor y más rápida difusión del trabajo publicado.
