Elementos de respuesta a estrés en el ovario y su implicancia en la fisiopatología ovárica en bovinos
Palabras clave:
ACTH, cortisol,, estrés,, ovario,, bovino.Resumen
En respuesta a varios estresores, la hormona adrenocorticotrópica estimula la síntesis y secreción de los glucocorticoides, los cuales pueden afectar la reproducción directamente por acción sobre el eje hipotálamo-hipófisis-ovario. En este sentido, es importante destacar que la ovulación ha sido descripta como un proceso inflamatorio localizado, donde una sucesión de eventos lleva a la degradación proteolítica de un punto específico de la pared folicular para permitir la salida del ovocito. Por lo tanto, el cortisol liberado a causa del estrés podría actuar a nivel del sitio ovulatorio inhibiendo la ovulación al producir efectos antiinflamatorios locales. Si bien no ha sido demostrado que el ovario sea capaz de producir glucocorticoides de novo, la hormona adrenocorticotrópica, a través de su unión a los receptores de melanocortinas en el ovario bovino, es capaz de estimular la secreción de hormonas esteroides tanto in vivo como in vitro, principalmente la secreción de cortisol, y producir cambios en la expresión de las enzimas 11?-hidroxiesteroide deshidrogenasas responsables de la activación/inactivación del cortisol. Nuestros resultados indican que la hormona adrenocorticotrópica puede estar implicada en los mecanismos regulatorios relacionados a la función ovárica asociados con la ovulación, la esteroidogénesis y la fisiopatología de diferentes enfermedades reproductivas en bovinos.
Palabras clave: ACTH, cortisol, estrés, ovario, bovino.
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AMWEG, A., SALVETTI, N., REY, F., & ORTEGA, H. (2015). Elementos de respuesta a estrés en el ovario y su implicancia en la fisiopatología ovárica en bovinos. Revista Ciencias Morfológicas, 17(2). Recuperado a partir de https://revistas.unlp.edu.ar/Morfol/article/view/2467
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