La proliferación celular de los sebocitos de ratón en la piel y la glándula prepucial
Resumen
Preputial glands are specialized sebaceous gland of some rodent as mouse and rat. This gland is regulated by androgens and other hormones. In this work we analysed the mitotic activity of the alveolar and ductal cells of the mice preputial gland throughout a circadian period. The results were compared to data obtained from the skin sebaceous gland. The mitotic activity in the preputial sebocytes displayed a bimodal curve with the highest mitotic indices at 12:00 and 00:00 h while the lower values were reached at 20:00 and 08:00h. In the ductal cells, the mitotic activity showed a single mitotic peak at 12:00h and a trough at 20:00 h. In the sebocytes from skin glands, the acrophase was detected at 04:00 h. The average cell proliferation daily value was significantly higher in the preputial sebocytes when compared to cutaneous sebocytes. These results demonstrated the existence of quantitative and qualitative differences in the mitotic activity of the preputial gland sebocytes in relation to the skin sebocytes.
Keywords: cell proliferation, circadian rhythms, preputial glands, sebocytes.
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Barbeito CG, García MN, Savignone CA, Catalano VA, Flamini MA, Badrán AF, Moreno FR. (1997). Actividad mitótica de los epitelios de epidermis, lengua, túbulos contorneados renales y conductos de la glándula submaxilar del ratón portador del tumor SS1K. Ciencias Morfológicas; 3: 9-18.
Barbeito CG, Surur JM, Badrán AF. (2000). Mitotic activity of the pars intermedia in the female mouse: ageassociated variations in proliferation rate and circadian periodicity. Chronobiol Int; 17:751-756.
Blanchard PG, Luu-The V. (2007). Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17 beta-hydroxysteroid dehydrogenase. J Endocrinol; 194:449-455.
Bronson FH, Marsden, HM. (1973). The preputial gland as an indicator of social dominance in male mice. Behav Biol; 9:625-628.
Deplewski D, Liao S, Rosenfield RL. (1997). Preputial sebocyte 5alpha-reductase isoform specificity. Endocrinol; 138:4416-4420.
Deplewski D, Rosenfield R. (1999). Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinol; 140:4089-4094.
Ebling FJ, Ebling E, Randall V, Skinner J. (1975). The effects of hypophysectomy and of bovine growth hormone on the responses to testosterone of prostate, preputial, Harderian and lachrymal glands and of brown adipose tissue in the rat. J Endocrinol; 66:401-406.
García MN, Barbeito CG, Andrini LB, Badrán AF. (2001). Circadian rhythm of the DNA synthesis and the mitotic activity of tongue keratinocytes. Cell Biol Int; 25:179-183.
Hay JB, Meddis D, Thody AJ, Shuster S. (1982). Mechanism of action of alpha-melanocyte-stimulating hormone in rat preputial glands: the role of androgen metabolism. J Endocrinol; 94:289-294.
Hayashi S. (1989). Male mice: Social Dominance Influenced by Strange Male Odors. Aggress Behav; 15:1-3.
Hayashi S. (1990). Social Condition Influences Sexual Attractiveness of Dominant Male Mice. Zool. Sci, 7: 889-894.
Homady M, Hussein H, Jiries A, Mahasneh A, Al-Nasir F, Khleifat K. (2002). Survey of Some Heavy Metals in Sediments from Vehicular Service Stations in Jordan and Their Effects on Social Aggression in Prepubertal Male Mice. Environmental Res; 89:43-49.
Huggins C, Parson FM, Jensen EV. (1955). Promotion and growth of preputial glands by steroids and the pituitary growth hormone. Endocrinol; 57:25-52.
Labrie F, Luu-The V, Martel C, Chernomoretz A, Calvo E, Morissette J, Labrie C. (2006). Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG). J Steroid Biochem Mol Biol; 100:52-58.
Lucas LA, Eleftheriou BE. (1980). Circadian variation in concentrations of testosterone in the plasma of male mice: a difference between BALB/cBy and C57BL/6By inbred strains. J Endocrinol; 87:37-46.
Marchlewska-Koj A, Pochron E, Sliwowska A (1990). Salivary glands and preputial glands of males as source of estrus-stimulating pheromone in female mice. J Chem Ecol, 16: 2817-2822.
Mednieks MI, Laurent SJ, Hand AR, Rosenfield RL. (1991). Cyclic AMP-receptor protein activity in rat preputial cells. J Inv Dermat; 97: 517523.
Miyake K, Ciletti N, Liao S, Rosenfield RL. (1994). Androgen receptor expression in the preputial gland and its sebocytes. J Inv Derm; 103, 721725.
Pelletier G, Luu-The V, Li S, Labrie F. 2005. Localization of type 8 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization. J Histochem Cytochem; 53:1257-1271.
Pohorecky LA, Blakley GG, Ma EW, Soini HA, Wiesler D, Bruce KE, Novotny MV. (2008). Social housing influences the composition of volatile compounds in the preputial glands of male rats. Hormones Behav; 53:536-545.
Potter JE, Prutkin L, Wheatley VR. (1979). Sebaceous gland differentiation. I. Separation, morphology and lipogenesis of isolated cells from the mouse preputial gland tumor. J Invest Dermatol; 72:120-127.
Rawdah K Al-Thani, Aisha S. Al-Thani, Elbetieha, A, Darmani H. (2003). Assessment of reproductive and fertility effects of amitraz pesticide in male mice. Toxicol Letters;138:253-260.
Sayegh JF, Kobor G, Lajtha A, Vadasz C. (1990). Effects of social isolation and the time of day on testosterone levels in plasma of C57BL/6By and BALB/cBy mice. Steroids; 55:79-82.
Sherins RJ, Bardin CW. (1971). Preputial gland growth and protein synthesis in the androgen-insensitive male pseudohermaphroditic rat. Endocrinol; 89:835-841.
Surur JM, Catalano VA, Flamini MA, Barbeito CG. (2005). Effects of tumors on the daily mitotic activity of mouse pars intermedia. Cell Biol Int; 29: 173-155.
Thiboutot D, Sivarajah A, Gilliland K, Cong Z, Clawson GJ. (2000). The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells. Invest Dermatol; 115:614-619.
Thody AJ, Shuster S. (1973). Possible role of MSH in the mammal. Nature; 245: 207-208,
Tsai TH, Scheving LE, Scheving LA, Pauly JE. (1985). Sex differences in circadian rhythms of several variables in lymphoreticular organs, liver, kidney, and corneal epithelium in adult CD2F1 mice. Anat Rec; 211:263-270.
Weinert D, Ulrich FE, Schuh J. (1987). Ontogenetic changes in the circadian rhythm of plasma insulin and its correlation to food intake. Biomed Biochim Acta; 46:387-395.
Wheatley VR, Potter JE, Lew G. (1979). Sebaceous gland differentiation: II. The isolation, separation and characterization of cells from the mouse preputial gland. J Invest Dermatol; 73:291-296.
Yamashita J, Hayashi S, Hirata Y. (1989). Reduced size of preputial glands and absence of aggressive behavior in the genetically obese (Ob/Ob) mouse. Zool Sci; 6:1033-1036.
Zhang JX, Rao XP, Sun L, Zhao CH, Qin XW. (2007). Putative chemical signals about sex, individuality, and genetic background in the preputial gland and urine of the house mouse (Mus musculus). Chem Senses; 32:293-303.
Barbeito CG, Surur JM, Badrán AF. (2000). Mitotic activity of the pars intermedia in the female mouse: ageassociated variations in proliferation rate and circadian periodicity. Chronobiol Int; 17:751-756.
Blanchard PG, Luu-The V. (2007). Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17 beta-hydroxysteroid dehydrogenase. J Endocrinol; 194:449-455.
Bronson FH, Marsden, HM. (1973). The preputial gland as an indicator of social dominance in male mice. Behav Biol; 9:625-628.
Deplewski D, Liao S, Rosenfield RL. (1997). Preputial sebocyte 5alpha-reductase isoform specificity. Endocrinol; 138:4416-4420.
Deplewski D, Rosenfield R. (1999). Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinol; 140:4089-4094.
Ebling FJ, Ebling E, Randall V, Skinner J. (1975). The effects of hypophysectomy and of bovine growth hormone on the responses to testosterone of prostate, preputial, Harderian and lachrymal glands and of brown adipose tissue in the rat. J Endocrinol; 66:401-406.
García MN, Barbeito CG, Andrini LB, Badrán AF. (2001). Circadian rhythm of the DNA synthesis and the mitotic activity of tongue keratinocytes. Cell Biol Int; 25:179-183.
Hay JB, Meddis D, Thody AJ, Shuster S. (1982). Mechanism of action of alpha-melanocyte-stimulating hormone in rat preputial glands: the role of androgen metabolism. J Endocrinol; 94:289-294.
Hayashi S. (1989). Male mice: Social Dominance Influenced by Strange Male Odors. Aggress Behav; 15:1-3.
Hayashi S. (1990). Social Condition Influences Sexual Attractiveness of Dominant Male Mice. Zool. Sci, 7: 889-894.
Homady M, Hussein H, Jiries A, Mahasneh A, Al-Nasir F, Khleifat K. (2002). Survey of Some Heavy Metals in Sediments from Vehicular Service Stations in Jordan and Their Effects on Social Aggression in Prepubertal Male Mice. Environmental Res; 89:43-49.
Huggins C, Parson FM, Jensen EV. (1955). Promotion and growth of preputial glands by steroids and the pituitary growth hormone. Endocrinol; 57:25-52.
Labrie F, Luu-The V, Martel C, Chernomoretz A, Calvo E, Morissette J, Labrie C. (2006). Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG). J Steroid Biochem Mol Biol; 100:52-58.
Lucas LA, Eleftheriou BE. (1980). Circadian variation in concentrations of testosterone in the plasma of male mice: a difference between BALB/cBy and C57BL/6By inbred strains. J Endocrinol; 87:37-46.
Marchlewska-Koj A, Pochron E, Sliwowska A (1990). Salivary glands and preputial glands of males as source of estrus-stimulating pheromone in female mice. J Chem Ecol, 16: 2817-2822.
Mednieks MI, Laurent SJ, Hand AR, Rosenfield RL. (1991). Cyclic AMP-receptor protein activity in rat preputial cells. J Inv Dermat; 97: 517523.
Miyake K, Ciletti N, Liao S, Rosenfield RL. (1994). Androgen receptor expression in the preputial gland and its sebocytes. J Inv Derm; 103, 721725.
Pelletier G, Luu-The V, Li S, Labrie F. 2005. Localization of type 8 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization. J Histochem Cytochem; 53:1257-1271.
Pohorecky LA, Blakley GG, Ma EW, Soini HA, Wiesler D, Bruce KE, Novotny MV. (2008). Social housing influences the composition of volatile compounds in the preputial glands of male rats. Hormones Behav; 53:536-545.
Potter JE, Prutkin L, Wheatley VR. (1979). Sebaceous gland differentiation. I. Separation, morphology and lipogenesis of isolated cells from the mouse preputial gland tumor. J Invest Dermatol; 72:120-127.
Rawdah K Al-Thani, Aisha S. Al-Thani, Elbetieha, A, Darmani H. (2003). Assessment of reproductive and fertility effects of amitraz pesticide in male mice. Toxicol Letters;138:253-260.
Sayegh JF, Kobor G, Lajtha A, Vadasz C. (1990). Effects of social isolation and the time of day on testosterone levels in plasma of C57BL/6By and BALB/cBy mice. Steroids; 55:79-82.
Sherins RJ, Bardin CW. (1971). Preputial gland growth and protein synthesis in the androgen-insensitive male pseudohermaphroditic rat. Endocrinol; 89:835-841.
Surur JM, Catalano VA, Flamini MA, Barbeito CG. (2005). Effects of tumors on the daily mitotic activity of mouse pars intermedia. Cell Biol Int; 29: 173-155.
Thiboutot D, Sivarajah A, Gilliland K, Cong Z, Clawson GJ. (2000). The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells. Invest Dermatol; 115:614-619.
Thody AJ, Shuster S. (1973). Possible role of MSH in the mammal. Nature; 245: 207-208,
Tsai TH, Scheving LE, Scheving LA, Pauly JE. (1985). Sex differences in circadian rhythms of several variables in lymphoreticular organs, liver, kidney, and corneal epithelium in adult CD2F1 mice. Anat Rec; 211:263-270.
Weinert D, Ulrich FE, Schuh J. (1987). Ontogenetic changes in the circadian rhythm of plasma insulin and its correlation to food intake. Biomed Biochim Acta; 46:387-395.
Wheatley VR, Potter JE, Lew G. (1979). Sebaceous gland differentiation: II. The isolation, separation and characterization of cells from the mouse preputial gland. J Invest Dermatol; 73:291-296.
Yamashita J, Hayashi S, Hirata Y. (1989). Reduced size of preputial glands and absence of aggressive behavior in the genetically obese (Ob/Ob) mouse. Zool Sci; 6:1033-1036.
Zhang JX, Rao XP, Sun L, Zhao CH, Qin XW. (2007). Putative chemical signals about sex, individuality, and genetic background in the preputial gland and urine of the house mouse (Mus musculus). Chem Senses; 32:293-303.
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BARBEITO, C. G., CATALANO, V. A., & GONZÁLEZ, N. V. (2014). La proliferación celular de los sebocitos de ratón en la piel y la glándula prepucial. Revista Ciencias Morfológicas, 9(2). Recuperado a partir de https://revistas.unlp.edu.ar/Morfol/article/view/941
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