Vassel invasion, vascular endotheliar groth factor receptor-2 (vegfr-2) expression and microvassel density in canine mammary carci
Abstract
One hundred and thirty six canine mammary carcinomas and their satellite lymph nodes were histological and histochemically studied. The aim of the present work was to assess the presence of carcinomatous emboli and the tumour angiogenic activity, the latter through the identification of VEGFR-2 (vascular endothelial growth factor receptor -2) and the counting of microvessels. The relation between the presence of emboli and angiogenesis and its impact on the status of the lymph nodes was established. Significant differences were found between tumours with and without emboli and their ability to cause metastasis in the lymph nodes. The extent of angiogenesis was higher in tumours that haddemonstrated carcinomatous emboli and / or metastasis.
Key words: canine, mammary carcinomas, vascular invasion, angiogenesis, prognosis.
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References
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Uva P, Aurisicchio L, Watters J, Loboda A, Kulkarni A, Castle J, Palombo F, Viti V, Mesiti G, Zappulli V,Marconato L, Abramo F, Ciliberto G, LahmA, LaMonica N, de Rinaldis E. (2009). Comparative expression pathway analysis of human and canine mammary tum.ors. BMC Genomics; 10:135-155.
Uzzan B, Nicolas P, Cucherat M, Perret GY. (2004). Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis. Cancer Res; 64: 2941-2955.
Westened PJ, Meurs qc, Damhuis RAM. (2005). Tumor size and vascular invasion predict distant metastasis instage 1breast cancer. Grade distinguishes early and late m.etastasis. / ClinPathol; 58: 196-201.
Chang S, Chang C, Chang T, Wong M. (2005). Prognostic factors associated with survival two years after surgery in dogswith malignant mammary tumors: 79cases (8-2002)./A VMA;'227(10):1625-1629.
Cullen JM, Page R, Misdorp W. (2002). An overview of cancer pathogenesis, diagnosis and management. En: Meuten DJ. Tum.ors inDomestic Animals. 4º ed.Ames: Iowa State University Press, pp. 3-36.
Greene FL, Page DL, Fleming ID (eds.) Fritz A, Balch CM:. (2002). AJCC Cancer Staging Handbook. Parte VII. 6°edición. New York: Springer Verlag. USA.
GuinebretiereJM. (2005). Angiogenesis and breast neoplasms. Thepathologistpoint of view. Gynécol Obstét Fertil; 33:140-146.
Hicklin DJ, Ellis LM. (2005). Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. ¡Clin Oncol; 23(5):1011-1027.
Itoh T, Uchida K,Ishikawa K,Kushim.a K,Kushim.a E, Tamada Het al. (2005). Clinicopathological survey of 101canine m.ammary gland tumors: differences between sm.all-breed dogs and others.] VetMed Sci; 67 (3): 345-347.
Kato T, Kameoka S, Kimura T, Nishikawa T, Kobayashi M. (2003). The combination of angiogenesis and blood vessel invasion asaprognostic indicator inprimary breast cancer. Br T Cancer; 88:1900-1908.
Millanta F, Silvestri G, Vaselli C, Citi S, Pisani G, Lorenzi D et al. (2006). The role of vascular endothelial growth factor and its receptor Flk-1/KDR in promoting tumour angiogenesis in feline and canine mammary carcinomas: A preliminary study of autocrine and paracrine loops. Res VetSci; 81:350-357.
Misdorp W, Else RW, Hellmén E, Llpscomb TP. (1999). Histological classification of mammary tumors of the dog and thecat. 2ºserie.Vol VII.Washington: AFIP. USA.
Nakopoulou L, Stefanaki K,Panayotopoulou E, Giannopoulou 1,Athanassiadou P, Gakiopoulou-Givalou H et al. (2002). Expression of the vascular endothelial growth factor receptor-2/Flk-1 in breast carcinomas: correlation with proliferation. Hum Pathology; 33 (9):863-869.
Parikh AA, Ellis LM. (2004). The vascular endothelial growth factor family and its receptors. Hematol Oncol Clin N Am; 18:951-971.
Restucci B, Borzacchiello G, Maiolino P, Martano M, Paciello O, Papparella S. (2004). Expression of vascular endothelial growth factor receptor Flk-1incanine mammary tumours.] CompPath; 130:99-104.
Restucci B, Papparella S, Maiolino P, De Vico G. (2002). Expression of vascular endothelial growth factor in canine mammary tumors. VetPathol; 39 (4):488-493.
Schoeffner DJ, Matheny SL, Akahane T, Factor V, Berry A, Merlino G et al. (2005). VEGF contributes to mammary tumor growth in transgenic mice through paracrine and autocrine mechanisms. Lab Invest; 85: 608-623.
Sharma S, Sharma MC, Sarkar C. (2005). Morphology of angiogenesis in human cancer: a conceptual overview, histoprognostic perspective and significance of neoangiogenesis. Histopathol; 46: 481-489.
Sleeman JP. (2000). The lymph node as a bridgehead in the metastatic dissemination of tum.ors. Recent Results Cancer Res; 157:55-81.
Sorenmo K. (2003). Canine mammary gland tumors. VetClin SmallAnim; 33:573-596.
Uva P, Aurisicchio L, Watters J, Loboda A, Kulkarni A, Castle J, Palombo F, Viti V, Mesiti G, Zappulli V,Marconato L, Abramo F, Ciliberto G, LahmA, LaMonica N, de Rinaldis E. (2009). Comparative expression pathway analysis of human and canine mammary tum.ors. BMC Genomics; 10:135-155.
Uzzan B, Nicolas P, Cucherat M, Perret GY. (2004). Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis. Cancer Res; 64: 2941-2955.
Westened PJ, Meurs qc, Damhuis RAM. (2005). Tumor size and vascular invasion predict distant metastasis instage 1breast cancer. Grade distinguishes early and late m.etastasis. / ClinPathol; 58: 196-201.
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DIESSLER, M., CASTELLANO, M. C., PORTINASKY, E. L., BURNS, S. L., & IDIART, J. R. (2014). Vassel invasion, vascular endotheliar groth factor receptor-2 (vegfr-2) expression and microvassel density in canine mammary carci. Revista Ciencias Morfológicas, 11(1). Retrieved from https://revistas.unlp.edu.ar/Morfol/article/view/928
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