Amitriptyline, the anti-inflammatory and anti-arthritic potential in Complete Freund’s Adjuvant -induced arthritic rats
Keywords:
CFA, pro-inflammatory cytokines, rheumatoid arthritis, ROS, superoxide dismutaseAbstract
This study was designed to evaluate the anti-arthritic potential of amitriptyline. The albumin was used for induction of acute inflammation in rats whereas chronic model was developed by using formaldehyde and Complete Freund’s Adjuvant (CFA). In acute inflammatory model, amitriptyline significantly (p<0.001) decreased the thickness of paw at early as well as late stages. At high dose of test drug, the significant (p<0.001) anti-inflammatory effect was noted in formaldehyde-induced arthritic model. Likewise, Amitriptyline (40 mg/kg oral dose) produced a 4.7 % decrease in swelling of paw prompted by CFA on day 14 that increased to 17.09 % on day 28. This effect significantly increased by higher dose of Amitriptyline 80 mg/kg (28.63 %) on day 28th. These findings validate the anti-arthritic effect of amitriptyline, but it has limitations for clinical studies.
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