La suplementación con colágeno hidrolizado en el deporte: una revisión narrativa
DOI:
https://doi.org/10.24215/30727731e011Palabras clave:
colágeno hidrolizado, ayudas ergogénicas, nutrición deportivaResumen
En los últimos años, la suplementación con colágeno hidrolizado ha despertado un creciente interés en el ámbito deportivo. En particular, se ha propuesto que su potencial capacidad para estimular la síntesis de proteínas del tejido conectivo, a través de mecanismos mediados por los fibroblastos, podría traducirse en beneficios sobre el rendimiento, la recuperación y los procesos de prevención y rehabilitación de lesiones. En este contexto, el objetivo de la presente revisión narrativa es examinar de manera crítica la evidencia disponible, con el fin de determinar si la suplementación con colágeno hidrolizado puede considerarse una intervención capaz de aportar beneficios significativos en atletas.
Descargas
Referencias
Alcock, R. D., Shaw, G. C., Tee, N. y Burke, L. M. (2019). Plasma amino acid concentrations after the ingestion of dairy and collagen proteins, in healthy active males. Frontiers in Nutrition, 6, 163. https://doi.org/10.3389/fnut.2019.00163
Aussieker, T., Kaiser, J., Hendriks, F. K., Janssen, T. A., Senden, J. M., Van Kranenburg, J. M. y Van Loon, L. J. (2025). The effects of ingesting a single bolus of hydrolyzed collagen versus free amino acids on muscle connective protein synthesis rates. Medicine and Science in Sports and Exercise, 57(11), 2394. https://doi.org/10.1249/MSS.0000000000003565
Aussieker, T., Hilkens, L., Holwerda, A. M., Fuchs, C. J., Houben, L. H., Senden, J. M. y Van Loon, L. J. (2023). Collagen protein ingestion during recovery from exercise does not increase muscle connective protein synthesis rates. Medicine and Science in Sports and Exercise, 55(10), 1792. https://doi.org/10.1249/MSS.0000000000003188
Bagi, C. M., Berryman, E. R., Teo, S. y Lane, N. E. (2017). Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA). Osteoarthritis and Cartilage, 25(12), 2080-2090. https://doi.org/10.1016/j.joca.2017.08.013
Benjakul, S., Karnjanapratum, S. y Visessanguan, W. (2018). Hydrolysed collagen from Lates calcarifer skin: Its acute toxicity and impact on cell proliferation and collagen production of fibroblasts. International Journal of Food Science and Technology, 53(8), 1871-1879. https://doi.org/10.1111/ijfs.13762
Bischof, K., Moitzi, A. M., Stafilidis, S. y König, D. (2024). Impact of collagen peptide supplementation in combination with long-term physical training on strength, musculotendinous remodeling, functional recovery, and body composition in healthy adults: a systematic review with meta-analysis. Sports Medicine, 54(11), 2865-2888. https://doi.org/10.1007/s40279-024-02025-6
Centner, C., Jerger, S., Mallard, A., Herrmann, A., Varfolomeeva, E., Gollhofer, S. y König, D. (2022). Supplementation of specific collagen peptides following high-load resistance exercise upregulates gene expression in pathways involved in skeletal muscle signal transduction. Frontiers in Physiology, 13, 838004. https://doi.org/10.3389/fphys.2022.838004
Choi, E., Kim, M., Lee, D. H., Shim, S., Kim, D. U., Hong, J. M. y Chung, H. C. (2025). Functional benefits of low-molecular-weight collagen peptide in cchilles tendon and medial collateral ligament injuries and anterior cruciate ligament transection-induced osteoarthritis. Journal of Microbiology and Biotechnology, 35, e2506035. https://doi.org/10.4014/jmb.2506.06035
Dar, Q. A., Schott, E. M., Catheline, S. E., Maynard, R. D., Liu, Z., Kamal, F. y Zuscik, M. J. (2017). Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. PloS One, 12(4), e0174705. https://doi.org/10.1371/journal.pone.0174705
De Almeida Jackix, E., Cúneo, F., Amaya-Farfan, J., de Assuncao, J. V. y Quintaes, K. D. (2010). A food supplement of hydrolyzed collagen improves compositional and biodynamic characteristics of vertebrae in ovariectomized rats. Journal of Medicinal food, 13(6), 1385-1390. https://doi.org/10.1089/jmf.2009.0160
DePhillipo, N. N., Aman, Z. S., Kennedy, M. I., Begley, J. P., Moatshe, G. y LaPrade, R. F. (2018). Efficacy of vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries: a systematic review. Orthopaedic Journal of Sports Medicine, 6(10), 2325967118804544. https://doi.org/10.1177/2325967118804544
Dierckx, S., Patrizi, M., Merino, M., González, S., Mullor, J. L. y Nergiz-Unal, R. (2024). Collagen peptides affect collagen synthesis and the expression of collagen, elastin, and versican genes in cultured human dermal fibroblasts. Frontiers in Medicine, 11, 1397517. https://doi.org/10.3389/fmed.2024.1397517
Edgar, S., Hopley, B., Genovese, L., Sibilla, S., Laight, D. y Shute, J. (2018). Effects of collagen-derived bioactive peptides and natural antioxidant compounds on proliferation and matrix protein synthesis by cultured normal human dermal fibroblasts. Scientific Reports, 8(1), 10474. https://doi.org/10.1038/s41598-018-28492-w
Elango, J., Hou, C., Bao, B., Wang, S., Maté Sánchez de Val, J. E. y Wenhui, W. (2022). The Molecular Interaction of Collagen with Cell Receptors for Biological Function. Polymers, 14(5), 876. https://doi.org/10.3390/polym14050876
Grădinaru, A. C. y Popa, S. (2025). Vitamin C: From self-sufficiency to dietary dependence in the framework of its biological functions and medical implications. Life, 15(2), 238. https://doi.org/10.3390/life15020238
Güz, B. C., Molenaar, R., De Jong, I. C., Kemp, B., Van Den Brand, H. y Van Krimpen, M. (2019). Effects of dietary organic minerals, fish oil, and hydrolyzed collagen on growth performance and tibia characteristics of broiler chickens. Poultry Science, 98(12), 6552-6563. https://doi.org/10.3382/ps/pez422
Hirayama, K., Iwanuma, S., Ikeda, N., Yoshikawa, A., Ema, R. y Kawakami, Y. (2017). Plyometric training favors optimizing muscle–tendon behavior during depth jumping. Frontiers in physiology, 8, 16. https://doi.org/10.3389/fphys.2017.00016
Holwerda, A. M. y van Loon, L. J. (2022). The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling: a narrative review. Nutrition Reviews, 80(6), 1497-1514. https://doi.org/10.1093/nutrit/nuab083
Honvo, G., Lengelé, L., Charles, A., Reginster, J. Y. y Bruyère, O. (2020). Role of collagen derivatives in osteoarthritis and cartilage repair: A systematic scoping review with evidence mapping. Rheumatology and Therapy, 7(4), 703-740. https://doi.org/10.1007/s40744-020-00234-5
Iwasaki, Y., Nakatogawa, M., Shimizu, A., Sato, Y. y Shigemura, Y. (2022). Comparison of gelatin and low-molecular weight gelatin hydrolysate ingestion on hydroxyproline (Hyp), Pro-Hyp and Hyp-Gly concentrations in human blood. Food Chemistry, 369, 130869. https://doi.org/10.1016/j.foodchem.2021.130869
Kamrani, P., Marston, G. y Jan, A. (2023). Anatomy, connective tissue. En StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK538496/
Kirmse, M., Lottmann, T. M., Volk, N. R., de Marées, M., Holwerda, A. M., van Loon, L. J. y Platen, P. (2024). Collagen peptide supplementation during training does not further increase connective tissue protein synthesis rates. Medicine and Science in Sports and Exercise, 56(12), 2296-2304. https://doi.org/10.1249/MSS.0000000000003516
Kishimoto, Y., Saito, N., Kurita, K., Shimokado, K., Maruyama, N. y Ishigami, A. (2013). Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts. Biochemical and Biophysical Research Communications, 430(2), 579-584. https://doi.org/10.1016/j.bbrc.2012.12.061
Kongsgaard, M., Kovanen, V., Aagaard, P., Doessing, S., Hansen, P., Laursen, A. H. y Magnusson, S. P. (2009). Corticosteroid injections, eccentric decline squat training and heavy slow resistance training in patellar tendinopathy. Scandinavian journal of Medicine and Science in Sports, 19(6), 790-802. https://doi.org/10.1111/j.1600-0838.2009.00949.x
Kubo, K., Kawakami, Y. y Fukunaga, T. (1999). Influence of elastic properties of tendon structures on jump performance in humans. Journal of Applied Physiology, 87(6), 2090-2096. https://doi.org/10.1152/jappl.1999.87.6.2090
Kubo, K., Yata, H., Kanehisa, H. y Fukunaga, T. (2006). Effects of isometric squat training on the tendon stiffness and jump performance. European Journal of Applied Physiology, 96(3), 305-314. https://doi.org/10.1007/s00421-005-0087-3
Kubo, K., Ikebukuro, T. y Yata, H. (2021). Effects of plyometric training on muscle–tendon mechanical properties and behavior of fascicles during jumping. Physiological Reports, 9(21), e15073. https://doi.org/10.14814/phy2.15073
Lee, J., Bridge, J. E., Clark, D. R., Stewart, C. E. y Erskine, R. M. (2023). Collagen supplementation augments changes in patellar tendon properties in female soccer players. Frontiers in Physiology, 14, 1089971. https://doi.org/10.3389/fphys.2023.1089971
León-López, A., Morales-Peñaloza, A., Martínez-Juárez, V. M., Vargas-Torres, A., Zeugolis, D. I. y Aguirre-Álvarez, G. (2019). Hydrolyzed collagen—sources and applications. Molecules, 24(22), 4031. https://doi.org/10.3390/molecules24224031
Lis, D. M., Jordan, M., Lipuma, T., Smith, T., Schaal, K. y Baar, K. (2021). Collagen and vitamin C supplementation increases lower limb rate of force development. International Journal of Sport Nutrition and Exercise Metabolism, 32(2), 65-73. https://doi.org/10.1123/ijsnem.2021-0199
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M. y Engebretsen, L. (2018). IOC consensus statement: dietary supplements and the high-performance athlete. International Journal of Sport Nutrition and Exercise Metabolism, 28(2), 104-125. https://doi.org/10.1123/ijsnem.2018-0020
McKendry, J., Lowisz, C. V., Nanthakumar, A., MacDonald, M., Lim, C., Currier, B. S. y Phillips, S. M. (2024). The effects of whey, pea, and collagen protein supplementation beyond the recommended dietary allowance on integrated myofibrillar protein synthetic rates in older males: A randomized controlled trial. The American Journal of Clinical Nutrition, 120(1), 34-46. https://doi.org/10.1016/j.ajcnut.2024.03.021
Muiznieks, L. D. y Keeley, F. W. (2013). Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1832(7), 866-875. https://doi.org/10.1016/j.bbadis.2012.11.022
Myung, S. K. y Park, Y. (2025). Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-analysis of Randomized Controlled Trials. The American Journal of Medicine. https://doi.org/10.1016/j.amjmed.2024.10.020
Ohara, H., Ichikawa, S., Matsumoto, H., Akiyama, M., Fujimoto, N., Kobayashi, T. y Tajima, S. (2010). Collagen‐derived dipeptide, proline‐hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. The Journal of Dermatology, 37(4), 330-338. https://doi.org/10.1111/j.1346-8138.2010.00827.x
Oikawa, S. Y., Kamal, M. J., Webb, E. K., McGlory, C., Baker, S. K. y Phillips, S. M. (2020). Whey protein but not collagen peptides stimulate acute and longer-term muscle protein synthesis with and without resistance exercise in healthy older women: A randomized controlled trial. The American Journal of Clinical Nutrition, 111(3), 708-718. https://doi.org/10.1093/ajcn/nqz332
Phillips, S. M. (2017). Current concepts and unresolved questions in dietary protein requirements and supplements in adults. Frontiers in Nutrition, 4, 13. https://doi.org/10.3389/fnut.2017.00013
Rennie, M. J., Edwards, R. H. T., Halliday, D., Matthews, D. E., Wolman, S. L. y Millward, D. J. (1982). Muscle protein synthesis measured by stable isotope techniques in man: The effects of feeding and fasting. Clinical Science, 63(6), 519-523. https://doi.org/10.1042/cs0630519
Secretaría de Agricultura, Ganadería y Pesca. (2024). Monitor: Incorporación de colágeno hidrolizado en suplementos dietarios (RESFC-2024-2-APN-SCS#MS). Alimentos Argentinos.
Shaw, G., Lee-Barthel, A., Ross, M. L., Wang, B. y Baar, K. (2017). Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis. The American Journal of Clinical Nutrition, 105(1), 136-143. https://doi.org/10.3945/ajcn.116.138594
Shoulders, M. D. y Raines, R. T. (2009). Collagen structure and stability. Annual Review of Biochemistry, 78(1), 929-958. https://doi.org/10.1146/annurev.biochem.77.032207.120833
Smeets, J. S., Horstman, A. M., Vles, G. F., Emans, P. J., Goessens, J. P., Gijsen, A. P. y Van Loon, L. J. (2019). Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans. PLoS One, 14(11), e0224745. https://doi.org/10.1371/journal.pone.0224745
Sun, Z., Guo, S. S. y Fässler, R. (2016). Integrin-mediated mechanotransduction. Journal of Cell Biology, 215(4), 445-456. https://doi.org/10.1083/jcb.201609037
Wang, J., Xu, M., Liang, R., Zhao, M., Zhang, Z. y Li, Y. (2015). Oral administration of marine collagen peptides prepared from chum salmon (Oncorhynchus keta) improves wound healing following cesarean section in rats. Food & Nutrition Research, 59(1), 26411. https://doi.org/10.3402/fnr.v59.26411
Wang, K., Meng, X. y Guo, Z. (2021). Elastin structure, synthesis, regulatory mechanism and relationship with cardiovascular diseases. Frontiers in Cell and Developmental Biology, 9, 596702. https://doi.org/10.3389/fcell.2021.596702
Wolfe, R. R. y Chinkes, D. L. (2004). Isotope tracers in metabolic research: Principles and practice of kinetic analysis. John Wiley & Sons.
Wu, J., Fujioka, M., Sugimoto, K., Mu, G. y Ishimi, Y. (2004). Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats. Journal of Bone and Mineral Metabolism, 22(6), 547-553. https://doi.org/10.1007/s00774-004-0522-2
Wu, M., Cronin, K. y Crane, J. S. (2018). Biochemistry, collagen synthesis. En StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK459358/
Zague, V., do Amaral, J. B., Rezende Teixeira, P., de Oliveira Niero, E. L., Lauand, C. y Machado‐Santelli, G. M. (2018). Collagen peptides modulate the metabolism of extracellular matrix by human dermal fibroblasts derived from sun‐protected and sun‐exposed body sites. Cell Biology International, 42(1), 95-104. https://doi.org/10.1002/cbin.10805
Zhang, Y., Akl, E. A. y Schünemann, H. J. (2019). Using systematic reviews in guideline development: The GRADE approach. Research Synthesis Methods, 10(3). https://doi.org/10.1002/jrsm.1313
Descargas
Publicado
Número
Sección
Licencia
Derechos de autor 2026 Fernando Luna, Joaquin Dacquino, Eugenio Viviani Rossi, Alejandro Garcia

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.












