Modificación de memorias maladaptativas durante el sueño y la vigilia: una visión interidisciplinaria

Matías Bonilla; Camila Isabel Jorge; Malen Daiana Moyano; Cecilia Forcato

doi:10.24215/2422572Xe073

Authors

Matías Bonilla Instituto Tecnológico de Buenos Aires (ITBA) (Argentina)
Camila Isabel Jorge Instituto Tecnológico de Buenos Aires (ITBA) (Argentina)
Malen Daiana Moyano Instituto Tecnológico de Buenos Aires (ITBA) (Argentina)
Cecilia Forcato Instituto Tecnológico de Buenos Aires (ITBA) (Argentina)

DOI:

https://doi.org/10.24215/2422572Xe073

Keywords:

reactivation, emotional memory, sleep, anxiety disorders

Abstract

Consolidated memories can return to a labile state after a reminder presentation (cue associated to the initial learning) followed by a re-stabilization process known as reconsolidation. Furthermore, sleep has an active role in the formation and modification of memories, as well as in decreasing the emotional tone of the experiences. During sleep, new memories are reactivated, reinforced and integrated into pre-existing networks. Within the therapeutic context, old memories can be retrieved according to the subject's needs, and this could be triggering repeated labilization/re-stabilization processes, perhaps without being aware of it. . In this review we discuss the neuroscientific advances regarding memory reactivation and modification during sleep and wakefulness, as well as the latest approaches in psychotherapeutic therapies for anxiety disorders, with the aim of thinking about a more interdisciplinary practice.

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Author Biographies

Matías Bonilla, Instituto Tecnológico de Buenos Aires (ITBA) (Argentina)

Estudiante avanzado de psicología (100% de las materias aprobadas, en la espera de defensa de tesis a causa de COVID-19). Estudiante doctoral, integrante del Laboratorio de Sueño y Memoria, departamento de Bioingeniería, ITBA. Actualmente me encuentro estudiando la formación de falsas memorias en diferentes rangos etarios.

Camila Isabel Jorge, Instituto Tecnológico de Buenos Aires (ITBA) (Argentina)

Estudiante de Psicología (UBA).

Malen Daiana Moyano, Instituto Tecnológico de Buenos Aires (ITBA) (Argentina)

Lic. en Biotecnología (UNQ). Actualmente becaria Doctoral CONICET en el Lab de Sueño y Memoria, Depto de Bioingeniería, ITBA. Estudio los mecanismos vinculados a la formación y modificación de memorias declarativas en humanos.

Cecilia Forcato, Instituto Tecnológico de Buenos Aires (ITBA) (Argentina)

Soy Lic. en Ciencias Biológicas de la Universidad de Buenos Aires, Doctora en el área de Ciencias Biológicas (UBA), Investigadora Adjunta CONICET, Profesora Asociada del Insituto Tecnológico de Buenos Aires y Docente de la Maestría en Neurociencias UNAJ. Soy Directora del Laboratorio de Sueño y Memoria, Depto de Bioingeniería, ITBA. Mis líneas de investigación se centran en el estudio de la modificación e integración de memorias durante el sueño y la vigilia, reforzamiento de memorias declarativas en adultos jóvenes, mayores y con deterioro cognitivo leve. Formación de falsas memorias en hechos delictivos. Sueño lúcido y experiencias fuera del cuerpo iniciadas desde la parálisis del sueño.

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