Ctrl-X, Ctrl-C y Ctrl-V en Dermatología Veterinaria: el trasplante de microbiota cutánea como un enfoque prometedor para perros con reacciones cutáneas adversas a los alimentos

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DOI:

https://doi.org/10.24215/15142590e080

Palabras clave:

Dermatitis atópica, intolerancia alimentaria, microbiota, piel, transferencia

Resumen

La posibilidad de influir en el microbioma cutáneo para tratar trastornos de la piel abre una nueva vía de terapéutica. El objetivo del presente trabajo fue evaluar la eficacia del trasplante de microbiota cutánea (sMt) para establecer las reacciones cutáneas adversas a los alimentos (caFr) en perros. Se realizó un sMt heterólogo no enriquecido utilizando tiras Nivea Skin Refining Clear-Up Strips (N-cUs). La microbiota bacteriana de las muestras de piel fue analizada mediante secuenciación de próxima generación del gen 16S rRNA. Otros biomarcadores relevantes permitieron establecer la puntuación del prurito (VAS), CADESI-04 y el análisis corneométrico epidérmico (hyidratación y pH). El gen 16S rRNA clasificó con éxito la presencia de un aumento de Faecalibacterium (0 a 1,9%), Peptoclostridium (5,49 % a 9,11 %) y Collinsella (0,65 % a 8,91 %), mientras que se observó una disminución de Fusobacterium (19,16 % a 9,06 %), Porphyromonas (8,75 % a 0,13 %), Streptococcus (1,63 % a 0,14 %) y Staphylococcus (1,09 % a 0,49 %), antes y después del sMt. El tratamiento con sMt controló eficazmente los signos clínicos y redujo significativamente la mediana del prurito VAS (6,5 vs. 2) y las puntuaciones CADESI-04 (74,50±22,62 a 19,30±11,30) (p<0,001). Además, los valores de pH e hidratación de la piel mejoraron (p<0,001) después de la sMt. La sMt heteróloga y no enriquecida con N-cUs podría ser responsable de la recuperación clínica observada en este estudio.

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Publicado

2024-04-16

Cómo citar

Ural, K., Erdoğan, H., & Erdoğan, S. (2024). Ctrl-X, Ctrl-C y Ctrl-V en Dermatología Veterinaria: el trasplante de microbiota cutánea como un enfoque prometedor para perros con reacciones cutáneas adversas a los alimentos. Analecta Veterinaria, 44, 080. https://doi.org/10.24215/15142590e080

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Trabajos de Investigación