Efecto sobre el crecimiento y desarrollo fetal de la administración de Ravenala madagascariensis Sonnerat (Strelitziaceae) durante la gestación
Estudio morfológico en un modelo murino
DOI:
https://doi.org/10.24215/18536387e126Palabras clave:
morfología, plantas medicinales, ratas Wistar, teratología experimental, toxicología reproductivaResumen
El objetivo de la investigación fue evaluar los efectos sobre el crecimiento y desarrollo fetal de la administración del extracto etanólico de hojas de Ravenala madagascariensis Sonnerat (Strelitziaceae) durante la gestación en ratas Wistar, mediante análisis morfológico externo, esquelético y visceral. Ratas gestadas se dividieron en dos grupos (n=10 por grupo): un grupo control (agua) y un grupo tratado (extracto etanólico seco de R. madagascariensis, 400 mg/kg), administrado en el agua de beber del día 5 al 15 de gestación. El día 20 de gestación, se realizó cesárea y eutanasia bajo anestesia. Se extrajeron los fetos y placentas para el examen morfológico externo inmediato. Los fetos seleccionados se sometieron a exámenes esqueléticos y viscerales. El extracto no alteró los niveles de glucemia fetal. En el grupo tratado, aunque no se modificó el tamaño fetal, se observó un aumento del peso fetal y de la eficiencia placentaria. No se identificaron fetos pequeños para la edad gestacional y se evidenció un incremento de la cantidad de fetos adecuados y grandes para la edad gestacional. El examen esquelético mostró un aumento del proceso de osificación de los parietales y de la primera falange de las patas anteriores. No se detectaron malformaciones esqueléticas o viscerales en ninguna de las regiones estudiadas. Aunque estos hallazgos indican un perfil de seguridad favorable para R. madagascariensis bajo estas condiciones experimentales específicas, se requieren más investigaciones para confirmar su seguridad y aplicaciones terapéuticas.
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Derechos de autor 2026 Cindy Freire-Gómez, Leticia Bequer Mendoza, Orelvis Portal, Katia Ojito-Ramos, Milagros García Rivero, Jose Luis Molina Martínez, Carolina Paschetta, Tahiry Gómez HernándezLa RAAB es una revista de acceso abierto tipo diamante. No se aplican cargos para la lectura, el envío de los trabajos ni tampoco para su procesamiento. Asímismo, los autores mantienen el copyright sobre sus trabajos así como también los derechos de publicación sin restricciones.
