Derivados de monatrol a partir de β-cetoésteres lipofílico por la reacción de Biginelli


  • Edna Ximena Aguilera Palacios Universidad Nacional de La Plata

Palabras clave:

Derivados, monastrol, β-cetoésteres, lipofílicos, Reacción de Biginelli


Las dihidropiridinas DHPMs son compuestos heterocíclicos de gran interés en la industria farmacológica por poseer múltiple actividad biológica en el tratamiento de diferentes enfermedades en especial contra el cáncer. La síntesis clásica se lleva a cabo mediante la reacción de Biginelli, sin embargo, nuevas estrategias se han estudiado modificando los compuestos de partida con el propósito de mejorar su eficiencia y minimizar su impacto ambiental. Una de las alternativas que ha sido poco explorada consiste en la modificación estructural de la molécula del monastrol a través de hibridación molecular o mediante un incremento en la lipofilicidad; en esta revisión corta se abordará algunas de las investigaciones que se han llevado a cabo desde compuestos de cadena larga demostrado que al aumentar la lipofilicidad tienen mayor actividad farmacológica.


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Cómo citar

Aguilera Palacios, E. X. (2022). Derivados de monatrol a partir de β-cetoésteres lipofílico por la reacción de Biginelli. Investigación Joven, 8(2), 26–32. Recuperado a partir de