Resistencia bacteriana a los antimicrobianos ocasionada por bombas de eflujo. Impacto en la multiresistencia

ML Marchetti; J Errecalde; N Mestorino

Authors

ML Marchetti
J Errecalde
N Mestorino

Keywords:

multidrug resistance, antimicrobial, efflux pump, bacteria

Abstract

Bacterial antimicrobial resistance is a serious problem worldwide. Several mechanisms of resistance have been described, among which are efflux pump systems. These systems are constituted by protein transporters organized in superfamilies and ubiquitously distributed among eukaryote and prokaryote organisms. The genes encoding efflux pumps can be found in the bacterial chromosome or in transmissible genetic elements such as plasmids. Some efflux pump systems may transport structurally dissimilar antimicrobial agents (Multiple Drug Resistance: MDR). Antibiotic efflux in association with other resistance mechanisms could confer high resistance level in commensal and pathogen bacteria causing consequent therapeutic failures. Due to the increasing importance of this microbial defense mechanism, several strategies to modify and reverse bacterial resistance by efflux pumps are currently being explored.

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