Toxina épsilon de Clostridium perfringens y su rol en la Enterotoxemia
DOI :
https://doi.org/10.24215/15142590e096Mots-clés :
toxina épsilon, Clostridium perfringens, enterotoxemia , diagnóstico, prevenciónRésumé
La toxina épsilon es una proteína reconocida por ser la tercera más potente dentro del género Clostridium, que forma parte de un grupo de bacterias anaerobias cosmopolitas productoras de toxinas. Epsilon pertenece al grupo de las toxinas formadoras de poros y es sintetizada en forma de protoxina relativamente inactiva, por los toxinotipos B y D de Clostridium perfringens. La protoxina se activa por clivaje proteolítico en intestino y es responsable de la enterotoxemia, una toxiinfección de curso agudo o subagudo que se caracteriza por la rapidez con que mata a los animales afectados, principalmente pequeños rumiantes.
Este artículo describe las principales toxinas asociadas a C. perfringens y se centra en la estructura, mecanismo de acción y rol de la toxina épsilon en el desarrollo de enterotoxemias. También se discuten alternativas de diagnóstico, control y prevención inmunoprofiláctica, junto con los candidatos vacunales experimentales descriptos hasta el presente.
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