Comparación de estrategias de suplementación para la prevención y tratamiento de la anemia ferropénica

Rocío Celeste Gambaro; Analía Seoane; Gisel Padula

doi:10.24215/18536387e065

Authors

Rocío Celeste Gambaro Instituto de Genética Veterinaria “Ing. Fernando N. Dulout” (IGEVET-UNLP-CONICET). Universidad Nacional de La Plata, La Plata, Argentina https://orcid.org/0000-0001-8376-4740
Analía Seoane Instituto de Genética Veterinaria “Ing. Fernando N. Dulout” (IGEVET-UNLP-CONICET). Universidad Nacional de La Plata, Argentina. https://orcid.org/0000-0001-9908-538X
Gisel Padula Instituto de Genética Veterinaria “Ing. Fernando N. Dulout” (IGEVET-UNLP-CONICET). Universidad Nacional de La Plata, Argentina. 2) Facultad de Ciencias Naturales y Museo (FCNyM). Universidad Nacional de La Plata (UNLP). La Plata, Argentina. https://orcid.org/0000-0001-5390-0043

DOI:

https://doi.org/10.24215/18536387e065

Keywords:

preventive health, therapeutics, iron, iron deficiency anemia

Abstract

The nutrition in the first 1000 days of human life is crucial to maintain the proper growth and development. In children one of the main malnutrition problems is iron deficiency. The Argentine Society of Pediatrics recommends daily doses with ferrous sulfate for preventive supplementation and also for therapeutic treatment, but in higher doses. Due to the adverse effects and the poor treatment compliance, the frequency of anemia iron deficiency continues to be very high which is why weekly supplementation emerges as an alternative. One of the invisible consequences associated with daily administration is that it can break the cellular balance and cause oxidative stress, causing damage to the main cellular biomolecules. The objective of this paper was to review the effectiveness of various forms of administration of preventive supplementation and therapeutic treatment for iron deficiency anemia. Likewise, studies where the effects of iron on oxidative stress and/or damage to biomolecules are evaluated. An exhaustive bibliographic search was carried out through different databases available online (Pubmed, Google Scholar, etc). Approximately 30 scientific articles in English and/or Spanish, carried out in vitro and in vivo, were selected. It is extremely important to review the current supplementation and treatment schemes to favor the design of adequate public health policies to deal with this universally distributed pathology.

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