Influencia del retardo del crecimiento intrauterino sobre la diferenciación craneana postnatal

  • Evelia E. Oyhenart
  • Maria F. Cesani Rossi
  • Héctor M. Pucciarelli

Resumen

RESUMEN: En las poblaciones humanas, el estudio de la adaptación gestacional al ambiente intrauterino se ve dificultado por la imposibilidad de establecer la fuente estresante primaria sumada al probable efecto amortiguador materno. La metodología experimental permite estudiar mejor los procesos de ajuste homeorréxico. El objeto del presente trabajo es evaluar el crecimiento craneano y la diferenciación sexual postnatal en individuos control y con retardo del crecimiento intrauterino (IUGR). Se emplearon ratas Wistar del Centro de Investigaciones en Genética Básica y Aplicada (CIGEBA). El efecto IUGR fue obtenido por obstrucción parcial de los vasos sanguíneos uterinos al día 15 de gestación, denominando a sus madres "operadas". Se trabajó con: (1) Crías control; (2) Crías IUGR amamantadas por madre operada; (3) Crías control amamantadas por madre operada; (4) Crías IUGR amamantadas por madre control. Todos los animales consumieron dieta stock ad-libitum y fueron sacrificados a los 42 días de edad. Se evaluó el peso corporal y se realizó un estudio métrico del neuro y del esplacnocráneo. Los resultados obtenidos permiten concluir que: (a) el efecto IUGR retrasó el crecimiento en peso corporal y en mediciones craneanas; (b) el esperado efecto catch-up en IUGRs con alimentación control no pudo ser observado; (c) los retrasos de crecimiento fueron mas marcados en los machos que en las hembras; y (d) a pesar que el tratamiento IUGR actuó sobre ambos sexos, una clara inhibición del dimorfismo sexual fue evidenciada en las variables craneofaciales. Rev. Arg. Antrop. Biol. 2(1): 135-150, 1999.

ABSTRACT: Adaptive processes in human and non human mammals can hardly be studied during gestation, since the main intrauterine sources of stress, together with eventual maternal softening effects, are difficult to detect. Experimentation allows improved studies on homeorrhesis fitting processes. The object of the present study was to evaluate the postnatal cranial growth and sexual dimorphism in both control and intrauterine growth retarded animals (IUGR). Wistar rats from the Centro de Investigaciones en Genética Básica y Aplicada (CIGEBA) were employed. The IUGR effect was achieved by partial obstruction of the uterine blood vessels in pregnant rats in the 15th day of gestation, the mothers being denominated "operated". The groups employed were: (1) controls; (2) IUGR pups suckled by operated dams; (3) control pups suckled by operated dams; and (4) IUGR pups suckled by control dams. All of the animals were fed by a stock diet ad-libitum, and sampled when they were 42 days old. Body weight, and metric variables from the neurocranium and face were employed for the evaluation of growth effects. It was found that: (a) the IUGR effect delayed growth in body weight and skull measurements; (b) the expected catch-up effects due to recovery were not shown; (c) growth delay was greater in males that in females; and (d) in spite that the IUGR treatment acted on both sexes, a plain arrest in sexual dimorphism was evident in the craniofacial variables. Rev. Arg. Antrop. Biol. 2(1): 135-150, 1999.

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Biografía del autor/a

Maria F. Cesani Rossi

Héctor M. Pucciarelli

Citas

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Cómo citar
Oyhenart, E. E., Cesani Rossi, M. F., & Pucciarelli, H. M. (1). Influencia del retardo del crecimiento intrauterino sobre la diferenciación craneana postnatal. Revista Argentina De Antropología Biológica, 2(1), 135-150. Recuperado a partir de https://revistas.unlp.edu.ar/raab/article/view/296
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