Influence of genetic and socio-environmental variables on excess weight in a sample population of Puerto Madryn, Argentina

Authors

  • Anahí Ruderman Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Argentina. https://orcid.org/0000-0002-9610-2997
  • Mariana Useglio Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Argentina. https://orcid.org/0009-0007-0190-828X
  • Virginia Ramallo Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Argentina. https://orcid.org/0000-0002-7856-4856
  • Carolina Paschetta Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Argentina. https://orcid.org/0000-0002-5869-3570
  • Soledad de Azevedo Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Argentina. https://orcid.org/0000-0003-4601-0717
  • Pablo Navarro Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Universidad Nacional del Sur, Universidad Nacional de la Patagonia San Juan Bosco, Argentina. https://orcid.org/0000-0003-2180-449X
  • Magda Alexandra Trujillo-Jiménez Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Argentina. https://orcid.org/0000-0001-5506-3496
  • Leonardo Morales Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Universidad Nacional del Sur, Universidad Nacional de la Patagonia San Juan Bosco, Argentina. https://orcid.org/0000-0002-3980-8862
  • Bruno Pazos Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Universidad Nacional del Sur, Universidad Nacional de la Patagonia San Juan Bosco, Argentina. https://orcid.org/0000-0002-0965-070X
  • Tamara Teodoroff  Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Argentina.
  • Rolando González-José  Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Argentina. https://orcid.org/0000-0002-8128-9381
  • Luis Orlando Pérez  Instituto Patagónico de Ciencias Sociales y Humanas, Subsecretaría de Ciencia y Tecnología, Argentina. https://orcid.org/0000-0003-2939-7753

DOI:

https://doi.org/10.24215/18536387e073

Keywords:

risk polymorphism, Argentine population, overweight

Abstract

In Argentina, obesity has been on the rise since 2005. The factors shown to be associated with obesity are of a socio environmental and genetic nature. Among the latter, the FTO gene has been the most extensively studied. The aim of the present work was to analyze the relationship between two markers of the FTO gene, namely rs9939609 and rs11075997, and socio environmental variables with nutritional status in a sample of 155 individuals from Puerto Madryn, Chubut. Body mass index (BMI) and waist-to height index (WHtR) were calculated, and multiple linear models were tested to determine the influence of genetic and non-genetic variables on these anthropometric indices. Nutritional status was significantly and negatively associated with educational level and physical activity. The allele reported in the literature as risk allele of the marker rs11075997 was significantly associated with an increase in anthropometric indices in an additive model, more so with WHtR than with BMI. It is necessary to carry out work on a larger scale that will allow us to determine the frequency of the genetic markers of predisposition to obesity studied here and their distribution in our country.

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Published

2024-04-08

How to Cite

Ruderman, A., Useglio, M., Ramallo, V., Paschetta, C., de Azevedo, S., Navarro, P., Trujillo-Jiménez, M. A., Morales, L., Pazos, B., Teodoroff, T., González-José, R., & Pérez, L. O. (2024). Influence of genetic and socio-environmental variables on excess weight in a sample population of Puerto Madryn, Argentina. Revista Argentina De Antropología Biológica, 26(1), 073. https://doi.org/10.24215/18536387e073

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